Predictive Male-to-Female Translation of Cardiac Electrophysiological Response to Drugs.
JACC Clin Electrophysiol
; 9(12): 2642-2648, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37768254
ABSTRACT
Despite evidence that women are at higher risk of drug-induced torsade de pointes and sudden cardiac death, female sex is vastly underrepresented in cardiovascular research, thus limiting our fundamental understanding of sex-specific arrhythmia mechanisms and our ability to predict arrhythmia propensity. To address this urgent clinical and preclinical need, we developed a quantitative tool that predicts the electrophysiological response to drug administration in female cardiomyocytes starting from data collected in males. We demonstrate the suitability of our translator for sex-specific cardiac safety assessment and include proof-of-concept application of our translator to in vitro and in vivo data.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do QT Longo
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
JACC Clin Electrophysiol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos