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Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation.
Sato, Yu; Hishinuma, Eiji; Yamazaki, Shuki; Ueda, Akiko; Kumondai, Masaki; Saito, Sakae; Tadaka, Shu; Kinoshita, Kengo; Nakayoshi, Tomoki; Oda, Akifumi; Maekawa, Masamitsu; Mano, Nariyasu; Hirasawa, Noriyasu; Hiratsuka, Masahiro.
Afiliação
  • Sato Y; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Hishinuma E; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Yamazaki S; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Ueda A; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Kumondai M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Saito S; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Tadaka S; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Kinoshita K; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Nakayoshi T; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Oda A; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Maekawa M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Mano N; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Hirasawa N; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
  • Hiratsuka M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.),
Drug Metab Dispos ; 51(12): 1561-1568, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37775333
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Varfarina / Família 4 do Citocromo P450 / Hipertensão Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Varfarina / Família 4 do Citocromo P450 / Hipertensão Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article