Design, synthesis and biological evaluation of new 1,&#969;-Bis-(5-alkyl-3-tosyl-1,3,4,2-triazaphospholino)alkanes as in vitro &#945;-amylase and lipase inhibitors.

Hamzaoui, Salwa; Salah, Bochra Ben; Bouguerra, Soumaya; Hamden, Khaled; Alghamdi, Othman A; Miled, Nabil; Kossentini, Mohamed

Design, synthesis and biological evaluation of new 1,ω-Bis-(5-alkyl-3-tosyl-1,3,4,2-triazaphospholino)alkanes as in vitro α-amylase and lipase inhibitors.

Hamzaoui, Salwa; Salah, Bochra Ben; Bouguerra, Soumaya; Hamden, Khaled; Alghamdi, Othman A; Miled, Nabil; Kossentini, Mohamed.

Afiliação

Hamzaoui S; Laboratory of Medicinal and Environnemental Chemistry, Higher Institute of Biotechnology of Sfax, University of Sfax, 3018 Sfax, Tunisia.
Salah BB; Laboratory of Medicinal and Environnemental Chemistry, Higher Institute of Biotechnology of Sfax, University of Sfax, 3018 Sfax, Tunisia. Electronic address: bensalah_bochra@yahoo.fr.
Bouguerra S; Laboratory of Electrochimistry and Environmental, Higher Institute of Ingenirous of Sfax, University of Sfax, 3038 Sfax, Tunisia.
Hamden K; Laboratory of Bioresources: Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia.
Alghamdi OA; University of Jeddah, College of Science, Department of Biological Sciences, Jeddah, Saudi Arabia.
Miled N; University of Jeddah, College of Science, Department of Biological Sciences, Jeddah, Saudi Arabia; Functional Genomics and Plant Physiology Unit, Higher Institute of Biotechnology of Sfax, 3038 Sfax, Tunisia.
Kossentini M; Laboratory of Medicinal and Environnemental Chemistry, Higher Institute of Biotechnology of Sfax, University of Sfax, 3018 Sfax, Tunisia.

Int J Biol Macromol ; 253(Pt 5): 127195, 2023 Dec 31.

Article em En | MEDLINE | ID: mdl-37793521

Assuntos

Inibidores Enzimáticos; alfa-Amilases; Estrutura Molecular; Relação Estrutura-Atividade; Inibidores Enzimáticos/química; Simulação de Acoplamento Molecular; alfa-Amilases/metabolismo; Alcanos; Lipase/metabolismo

Palavras-chave

1,ω-bis(1-tosylamidrazone)alkanes; 1,ω-bis(5-alkyl-3-tosyl-1,3,4,2-triazaphospholine-2-oxide)alkanes; Diabetes; Lawesson's reagent; Obesity; Trisdimethylaminophosphine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Alfa-Amilases Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Tunísia

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