Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells.

Li, Yuxi; Li, Xilin; Cournoyer, Patrick; Choudhuri, Supratim; Guo, Lei; Chen, Si

Li, Yuxi; Li, Xilin; Cournoyer, Patrick; Choudhuri, Supratim; Guo, Lei; Chen, Si.

Afiliação

Li Y; Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA.
Li X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Cournoyer P; Office of the Commissioner, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA.
Choudhuri S; Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.
Guo L; Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA.
Chen S; Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Si.Chen@fda.hhs.gov.

Arch Toxicol ; 97(12): 3227-3241, 2023 12.

Article em En | MEDLINE | ID: mdl-37794255

Assuntos

Canabidiol; Canabinoides; Masculino; Animais; Humanos; Canabidiol/toxicidade; Teorema de Bayes; Células Intersticiais do Testículo; Apoptose

Palavras-chave

7-Carboxy-CBD; 7-Hydroxy-CBD; Apoptosis; Cannabidiol; Cell cycle arrest; DNA synthesis; Leydig cells; Male reproductive toxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol / Canabinoides Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Arch Toxicol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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