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Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location.
Ojala, Ronja; Hentilä, Jaakko; Lietzén, Martin S; Arponen, Milja; Heiskanen, Marja A; Honkala, Sanna M; Virtanen, Heidi; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Heinonen, Olli J; Malm, Tarja; Lahti, Leo; Rinne, Juha; Eskola, Olli; Rajander, Johan; Pietiläinen, Kirsi H; Kaprio, Jaakko; Ivaska, Kaisa K; Hannukainen, Jarna C.
Afiliação
  • Ojala R; Turku PET Centre, University of Turku, Turku, Finland.
  • Hentilä J; Turku PET Centre, University of Turku, Turku, Finland.
  • Lietzén MS; Turku PET Centre, University of Turku, Turku, Finland.
  • Arponen M; Institute of Biomedicine, University of Turku, Turku, Finland.
  • Heiskanen MA; Turku PET Centre, University of Turku, Turku, Finland.
  • Honkala SM; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
  • Virtanen H; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
  • Koskensalo K; Turku PET Centre, University of Turku, Turku, Finland.
  • Lautamäki R; Turku PET Centre, University of Turku, Turku, Finland.
  • Löyttyniemi E; Department of Medical Physics, Turku University Hospital, Turku, Finland.
  • Parkkola R; Heart Centre, Turku University Hospital, Turku, Finland.
  • Heinonen OJ; Department of Biostatistics, University of Turku, Turku, Finland.
  • Malm T; Department of Radiology, University of Turku, Turku, Finland.
  • Lahti L; Department of Radiology, Turku University Hospital, Turku, Finland.
  • Rinne J; Paavo Nurmi Centre, Department of Health and Physical Activity, University of Turku, Turku, Finland.
  • Eskola O; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
  • Rajander J; Department of Computing, University of Turku, Turku, Finland.
  • Pietiläinen KH; Turku PET Centre, University of Turku, Turku, Finland.
  • Kaprio J; Turku PET Centre, Turku University Hospital, Turku, Finland.
  • Ivaska KK; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
  • Hannukainen JC; Turku PET Centre, Accelerator Laboratory, Åbo Akademi University, Turku, Finland.
Diabetes Obes Metab ; 26(1): 251-261, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37818602
ABSTRACT

AIM:

High body weight is a protective factor against osteoporosis, but obesity also suppresses bone metabolism and whole-body insulin sensitivity. However, the impact of body weight and regular training on bone marrow (BM) glucose metabolism is unclear. We studied the effects of regular exercise training on bone and BM metabolism in monozygotic twin pairs discordant for body weight.

METHODS:

We recruited 12 monozygotic twin pairs (mean ± SD age 40.4 ± 4.5 years; body mass index 32.9 ± 7.6, mean difference between co-twins 7.6 kg/m2 ; eight female pairs). Ten pairs completed the 6-month long training intervention. We measured lumbar vertebral and femoral BM insulin-stimulated glucose uptake (GU) using 18 F-FDG positron emission tomography, lumbar spine bone mineral density and bone turnover markers.

RESULTS:

At baseline, heavier co-twins had higher lumbar vertebral BM GU (p < .001) and lower bone turnover markers (all p < .01) compared with leaner co-twins but there was no significant difference in femoral BM GU, or bone mineral density. Training improved whole-body insulin sensitivity, aerobic capacity (both p < .05) and femoral BM GU (p = .008). The training response in lumbar vertebral BM GU was different between the groups (time × group, p = .02), as GU tended to decrease in heavier co-twins (p = .06) while there was no change in leaner co-twins.

CONCLUSIONS:

In this study, regular exercise training increases femoral BM GU regardless of weight and genetics. Interestingly, lumbar vertebral BM GU is higher in participants with higher body weight, and training counteracts this effect in heavier co-twins even without reduction in weight. These data suggest that BM metabolism is altered by physical activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Resistência à Insulina Limite: Adult / Female / Humans Idioma: En Revista: Diabetes Obes Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Finlândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Resistência à Insulina Limite: Adult / Female / Humans Idioma: En Revista: Diabetes Obes Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Finlândia