The Chemical Biology of NO that Regulates Oncogenic Signaling and Metabolism: NOS2 and Its Role in Inflammatory Disease.
Crit Rev Oncog
; 28(1): 27-45, 2023.
Article
em En
| MEDLINE
| ID: mdl-37824385
ABSTRACT
Nitric oxide (NO) and the enzyme that synthesizes it, nitric oxide synthase 2 (NOS2), have emerged as key players in inflammation and cancer. Expression of NOS2 in tumors has been correlated both with positive outcomes and with poor prognoses. The chemistry of NO is the major determinate to the biological outcome and the concentration of NO, which can range over five orders of magnitude, is critical in determining which pathways are activated. It is the activation of specific oncogenic and immunological mechanisms that shape the outcome. The kinetics of specific reactions determine the mechanisms of action. In this review, the relevant reactions of NO and related species are discussed with respect to these oncogenic and immunological signals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óxido Nítrico Sintase Tipo II
/
Neoplasias
/
Óxido Nítrico
Limite:
Humans
Idioma:
En
Revista:
Crit Rev Oncog
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2023
Tipo de documento:
Article