Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation.

Okolo, Chidinma A; Khaing, Ei-Phyo; Mereacre, Valeria; Wallace, Rachel S; Munro, Michelle L; Erickson, Jeffrey R; Jones, Peter P

Okolo, Chidinma A; Khaing, Ei-Phyo; Mereacre, Valeria; Wallace, Rachel S; Munro, Michelle L; Erickson, Jeffrey R; Jones, Peter P.

Afiliação

Okolo CA; Department of Physiology, School of Biomedical Sciences, Division of Health Sciences, and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Khaing EP; Beamline B24, Life Sciences Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, England, United Kingdom.
Mereacre V; Department of Physiology, School of Biomedical Sciences, Division of Health Sciences, and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Wallace RS; Department of Physiology, School of Biomedical Sciences, Division of Health Sciences, and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Munro ML; Department of Physiology, School of Biomedical Sciences, Division of Health Sciences, and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Erickson JR; Department of Physiology, School of Biomedical Sciences, Division of Health Sciences, and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Jones PP; Department of Physiology, School of Biomedical Sciences, Division of Health Sciences, and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.

Cardiovasc Diabetol ; 22(1): 276, 2023 10 13.

Article em En | MEDLINE | ID: mdl-37833717

Assuntos

Diabetes Mellitus; Canal de Liberação de Cálcio do Receptor de Rianodina; Animais; Humanos; Canal de Liberação de Cálcio do Receptor de Rianodina/genética; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Miócitos Cardíacos/metabolismo; Células HEK293; Fosforilação/fisiologia; Retículo Sarcoplasmático/metabolismo; Diabetes Mellitus/metabolismo; Serina/metabolismo; Treonina/metabolismo; Cálcio/metabolismo

Palavras-chave

Diabetes; O-GlcNAcylation; Ryanodine receptor (RyR2); SOICR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canal de Liberação de Cálcio do Receptor de Rianodina / Diabetes Mellitus Limite: Animals / Humans Idioma: En Revista: Cardiovasc Diabetol Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Nova Zelândia

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