Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase.

Vishakantegowda, Avinash G; Girmay, Berehe Solomon; Shin, Jin Soo; Lee, Joo-Youn; Ahn, Sunjoo; Jung, Young-Sik

Vishakantegowda, Avinash G; Girmay, Berehe Solomon; Shin, Jin Soo; Lee, Joo-Youn; Ahn, Sunjoo; Jung, Young-Sik.

Afiliação

Vishakantegowda AG; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, Republic of Korea.
Girmay BS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, Republic of Korea.
Shin JS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Lee JY; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Ahn S; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Jung YS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, Republic of Korea. Electronic address: ysjung@krict.re.kr.

Bioorg Med Chem Lett ; 96: 129504, 2023 11 15.

Article em En | MEDLINE | ID: mdl-37838342

Assuntos

Reativadores da Colinesterase; Oximas; Oximas/farmacologia; Oximas/química; Paraoxon/farmacologia; Acetilcolinesterase/metabolismo; Reativadores da Colinesterase/farmacologia; Reativadores da Colinesterase/química; Inibidores da Colinesterase/farmacologia; Inibidores da Colinesterase/química; Simulação de Acoplamento Molecular; Compostos de Piridínio/farmacologia; Compostos de Piridínio/química; Acetamidas; Compostos Organofosforados/química

Palavras-chave

Acetylcholinesterase; Organophosphorus agents; Oxime; Reactivator

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Reativadores da Colinesterase Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article

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