Challenges integrating skin sensitization data for assessment of difficult to test substances.
ALTEX
; 41(1): 104-118, 2024 01 09.
Article
em En
| MEDLINE
| ID: mdl-37843019
Non-animal test methods to detect chemicals that cause skin allergies are accepted alternatives to animal testing for this purpose. However, some chemicals are difficult to test using these methods, e.g., substances that cause skin irritation, are not water soluble or are mixtures of different components. We compiled existing and new data on how four such chemicals activate key elements of the biological pathway leading to allergic skin reactions and compared the resulting patterns with respective patterns of many chemicals confirmed to cause skin allergy, skin irritation or neither. The patterns were visualized and analyzed with a computer software tool. The tool confirmed that three substances were non-sensitizers but did not confirm that the fourth substance was a skin sensitizer as predicted by the standard assessment. This approach, which incorporates all available data types into the assessment of difficult to test chemicals, may further reduce unnecessary animal testing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatite Alérgica de Contato
/
Rotas de Resultados Adversos
Limite:
Humans
Idioma:
En
Revista:
ALTEX
Assunto da revista:
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos