Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.
HIV Med
; 25(2): 233-244, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37845017
ABSTRACT
BACKGROUND:
The role of body fat on metabolic complications remains poorly understood in young people living with perinatally acquired HIV (YPHIV).OBJECTIVE:
Our objective was to assess the association of changes in adiposity over 2 years with metabolic outcomes in YPHIV.METHODS:
The PHACS Adolescent Master Protocol (AMP) study enrolled YPHIV from 2007 to 2009 across 15 US sites, including Puerto Rico. We included YPHIV aged 7-19 years with body composition data assessed by whole-body dual-energy X-ray absorptiometry (DXA) at baseline and 2 years later. Metabolic outcomes included homeostatic model assessment of insulin resistance (HOMA-IR) and non-high-density lipoprotein cholesterol (non-HDL-C). We fitted linear regression models to assess the association of increase in body fat over 2 years with metabolic outcomes at years 2 and 3.RESULTS:
In all, 232 participants had a second DXA and either HOMA-IR or non-HDL-C measured at year 2. Participant characteristics at the first DXA were age 12 years (9-14) [median (Q1-Q3)], 69% Black, and median CD4 count 714 cells/µL; 70% with HIV RNA <400 copies/mL. In adjusted analyses for every 1% increase in body fat from baseline to year 2, HOMA-IR was higher by 1.03-fold at year 3 (95% CI 1.00, 1.05). We observed that for every 1% increase in body fat from baseline to year 2, non-HDL-C was 0.72 mg/dL higher at year 2 (95% CI -0.04-1.49) and 0.81 mg/dL higher at year 3 (95% CI -0.05-1.66).CONCLUSIONS:
Increases in adiposity over time may lead to downstream decreased insulin sensitivity and dyslipidaemia in YPHIV.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Infecções por HIV
Limite:
Adolescent
/
Humans
Idioma:
En
Revista:
HIV Med
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos