CDK4/6 inhibitors induce breast cancer senescence with enhanced anti-tumor immunogenic properties compared with DNA-damaging agents.

Lee, Dong Hyun; Imran, Muhammad; Choi, Jae Ho; Park, Yoo Jung; Kim, Young Hwa; Min, Sunwoo; Park, Tae Jun; Choi, Yong Won

Lee, Dong Hyun; Imran, Muhammad; Choi, Jae Ho; Park, Yoo Jung; Kim, Young Hwa; Min, Sunwoo; Park, Tae Jun; Choi, Yong Won.

Afiliação

Lee DH; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
Imran M; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.
Choi JH; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon, Korea.
Park YJ; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
Kim YH; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon, Korea.
Min S; Inflamm-Aging Translational Research Center, Ajou University Medical Center, Suwon, Korea.
Park TJ; Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea.
Choi YW; Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea.

Mol Oncol ; 18(1): 216-232, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37854019

Assuntos

Neoplasias da Mama; Humanos; Feminino; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/patologia; NF-kappa B/metabolismo; Senescência Celular/genética; Microambiente Tumoral; Quinase 4 Dependente de Ciclina

Palavras-chave

CDK4/6 inhibitors; DNA-damaging agents; SASP; therapy-induced senescence; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Limite: Female / Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article

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