Biomimetic Polyphenolic Scaffolds with Antioxidative Abilities for Improved Bone Regeneration.
ACS Appl Bio Mater
; 6(11): 4586-4591, 2023 11 20.
Article
em En
| MEDLINE
| ID: mdl-37856084
ABSTRACT
Bone defects have a severe impact on the health and lives of patients due to their long-lasting and difficult-to-treat features. Recent studies have shown that there are complex microenvironments, including excessive production of reactive oxygen species. Herein, a surface functionalization strategy using metal-polyphenolic networks was used, which was found to be beneficial in restoring oxidative balance and enhancing osseointegration. The surface properties, biocompatibility, intracellular ROS scavenging, and osseointegration capacity were evaluated, and the therapeutic effects were confirmed using a skull defect model. This approach has great potential to improve complex microenvironments and enhance the efficiency of bone tissue regeneration.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomimética
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
ACS Appl Bio Mater
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China