The Association of Melanoma-Associated Antigen-C Gene With Clinicopathological Characteristics and Prognosis in Breast Cancer: A Systematic Review and Meta-Analysis.
Clin Breast Cancer
; 24(1): 7-16, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-37872029
ABSTRACT
To investigate the correlation of melanoma-associated antigen-C gene expression with clinicopathologic characteristics and prognosis in patients with breast cancer through a meta-analysis. PubMed, Embase, Web of Science, Cochrane, CNKI, Wanfang and VIP databases were searched from the establishment of the databases to December 2022. The New castle-Ottawa Scale (NOS) was used for literature quality evaluation, and meta-analysis of all studies was performed using Rev Man 5.3 and Stata14.0. A total of 11 studies and 1146 samples were included in the meta-analysis. High expression of MAGE-C gene was significantly correlated with tumor grade (OR = 8.06, 95%CI4.14-15.67, P < .00001), lymph node metastasis (OR = 8.06, 95%CI4.14-15.67, P < .00001), tumor type (OR = 0.36, 95%CI 0.23-0.49, P < .00001), tumor stage (OR = 0.14, 95%CI 0.05-0.38, P = .0001<.05), ER expression (OR = 0.14, 95%CI 0.05-0.38, P = .0001<.05), HER-2 expression (OR = 0.24, 95%CI0.11-0.57, P = .001<.05) and tumor embolus (OR = 0.24, 95%CI0.11-0.57, P = .001<.05). In addition, the MAGE-C expression was correlated with the reduced overall survival (HR = 2.13, 95%CI 1.52-2.99, P < .0001), recurrence-free survival (HR = 2.59, 95%CI1.47-4.56, P = .0010) and metastasis-free survival (OR = 2.52, 95%CI 1.38-4.59, P = .003). The high expression of MAGE-C gene is closely related to some clinicopathological parameters and poor prognosis of breast cancer, which may be used as a potential biomarker to determine the prognosis of breast cancer.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Melanoma
Tipo de estudo:
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Revista:
Clin Breast Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China