Impact of persistent pulmonary hypertension and oxygenation on brain injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia.
J Perinatol
; 44(4): 513-520, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37872383
ABSTRACT
OBJECTIVE:
To investigate the effects of persistent pulmonary hypertension (PPHN) and oxygenation on outcome of neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH). STUDYDESIGN:
We compared the outcome of neonates with NE treated with TH with or without PPHN.RESULTS:
384 neonates with NE were treated with TH; 24% had PPHN. The fraction of inspired oxygen was higher in the first 4 days of life (p < 0.001) in neonates with PPHN. They had a significantly lower arterial partial pressure of oxygen in the first 4 days of life (p = 0.005) and higher on days 3-4 of life (p < 0.001). They were more often intubated (p < 0.001) and more often had concomitant hypotension (p < 0.001). They had higher mortality (p = 0.009) and more often developed brain injury (p = 0.02).CONCLUSION:
PPHN occurred frequently in neonates with NE treated with TH and was associated with a higher incidence of adverse outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome da Persistência do Padrão de Circulação Fetal
/
Lesões Encefálicas
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Hipertensão Pulmonar
/
Hipotermia Induzida
/
Doenças do Recém-Nascido
Limite:
Humans
/
Newborn
Idioma:
En
Revista:
J Perinatol
Assunto da revista:
PERINATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá