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Development of 18F-Labeled hydrophilic trans-cyclooctene as a bioorthogonal tool for PET probe construction.
Xu, Muyun; Ma, Xinrui; Pigga, Jessica E; Zhang, He; Wang, Shuli; Zhao, Weiling; Deng, Huaifu; Wu, Anna M; Liu, Rihe; Wu, Zhanhong; Fox, Joseph M; Li, Zibo.
Afiliação
  • Xu M; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Ma X; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Pigga JE; Department of Chemistry, the University of Delaware, Newark, Delaware, 19716, USA. jmfox@udel.edu.
  • Zhang H; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Wang S; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Zhao W; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Deng H; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Wu AM; Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California, 91010, USA.
  • Liu R; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Wu Z; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
  • Fox JM; Department of Chemistry, the University of Delaware, Newark, Delaware, 19716, USA. jmfox@udel.edu.
  • Li Z; Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. zhanhong_wu@med.unc.edu.
Chem Commun (Camb) ; 59(97): 14387-14390, 2023 Dec 05.
Article em En | MEDLINE | ID: mdl-37877355
ABSTRACT
We report the development of a hydrophilic 18F-labeled a-TCO derivative [18F]3 (log P = 0.28) through a readily available precursor and a single-step radiofluorination reaction (RCY up to 52%). We demonstrated that [18F]3 can be used to construct not only multiple small molecule/peptide-based PET agents, but protein/diabody-based imaging probes in parallel.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclo-Octanos / Tomografia por Emissão de Pósitrons Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclo-Octanos / Tomografia por Emissão de Pósitrons Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos