Future trends for patient-specific dosimetry methodology in molecular radiotherapy.
Phys Med
; 115: 103165, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37880071
ABSTRACT
Molecular radiotherapy is rapidly expanding, and new radiotherapeutics are emerging. The majority of treatments is still performed using empirical fixed activities and not tailored for individual patients. Molecular radiotherapy dosimetry is often seen as a promising candidate that would allow personalisation of treatments as outcome should ultimately depend on the absorbed doses delivered and not the activities administered. The field of molecular radiotherapy dosimetry has made considerable progress towards the feasibility of routine clinical dosimetry with reasonably accurate absorbed-dose estimates for a range of molecular radiotherapy dosimetry applications. A range of challenges remain with respect to the accurate quantification, assessment of time-integrated activity and absorbed dose estimation. In this review, we summarise a range of technological and methodological advancements, mainly focussed on beta-emitting molecular radiotherapeutics, that aim to improve molecular radiotherapy dosimetry to achieve accurate, reproducible, and streamlined dosimetry. We describe how these new technologies can potentially improve the often time-consuming considered process of dosimetry and provide suggestions as to what further developments might be required.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radiometria
/
Planejamento da Radioterapia Assistida por Computador
Limite:
Humans
Idioma:
En
Revista:
Phys Med
Assunto da revista:
BIOFISICA
/
BIOLOGIA
/
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article