Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism.

Guo, Qiaoyue; Chen, Ningrong; Patel, Kalp; Wan, Mei; Zheng, Junying; Cao, Xu

Guo, Qiaoyue; Chen, Ningrong; Patel, Kalp; Wan, Mei; Zheng, Junying; Cao, Xu.

Afiliação

Guo Q; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Chen N; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China.
Patel K; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Wan M; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Zheng J; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Cao X; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Adv Sci (Weinh) ; 10(35): e2305042, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37880864

Assuntos

Dinoprostona; Interocepção; Humanos; Camundongos; Animais; Dinoprostona/metabolismo; Neuropeptídeo Y/metabolismo; Hipotálamo/metabolismo; Neurônios/metabolismo

Palavras-chave

bone metabolism; microgravity; neuropeptide Y (NPY); skeletal interoception; tyrosine hydroxylase (TH)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dinoprostona / Interocepção Limite: Animals / Humans Idioma: En Revista: Adv Sci (Weinh) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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