Studies of arylthiazole oxamates in relation to oral antiallergic activity.
Arzneimittelforschung
; 36(9): 1391-3, 1986 Sep.
Article
em En
| MEDLINE
| ID: mdl-3790192
ABSTRACT
25 arylthiazole oxamate derivatives were synthesized and examined for antiallergic activity in the rat passive cutaneous anaphylaxis assay. These compounds were prepared by treatment of the appropriate bromoacetophenone with thioureas to give arylaminothiazoles. Further condensation with alkyloxalyl chloride gave the arylthiazolyl oxamates. Several derivatives showed a 70% inhibition at 5 mg/kg p.o. p-Alkoxy substitution on the phenyl ring resulted in enhanced activity while N-alkyl substitution on the nitrogen amide function inhibited the activity. Ethyl-N-(4-p-methoxyphenyl)-2-thiazolyl oxamate (tioxamast, F-1865) was selected for clinical studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Oxâmico
/
Tiazóis
/
Anafilaxia Cutânea Passiva
/
Aminoácidos
Limite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1986
Tipo de documento:
Article