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Multi-institutional analysis of aneuploidy and outcomes to chemoradiation and durvalumab in stage III non-small cell lung cancer.
Alessi, Joao V; Price, Adam; Richards, Allison L; Ricciuti, Biagio; Wang, Xinan; Elkrief, Arielle; Pecci, Federica; Di Federico, Alessandro; Gandhi, Malini M; Lebow, Emily S; Santos, Patricia Mae G; Thor, Maria; Rimner, Andreas; Schoenfeld, Adam J; Chaft, Jamie E; Johnson, Bruce E; Gomez, Daniel R; Awad, Mark M; Shaverdian, Narek.
Afiliação
  • Alessi JV; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Price A; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Richards AL; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Ricciuti B; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Wang X; Environmental Health, Harvard University, Boston, Massachusetts, USA.
  • Elkrief A; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Pecci F; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Di Federico A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Gandhi MM; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Lebow ES; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Santos PMG; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Thor M; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Rimner A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Schoenfeld AJ; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Chaft JE; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Johnson BE; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Gomez DR; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Awad MM; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Shaverdian N; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
J Immunother Cancer ; 11(11)2023 11.
Article em En | MEDLINE | ID: mdl-37914383
There is a need to identify predictive biomarkers to guide treatment strategies in stage III non-small cell lung cancer (NSCLCs). In this multi-institutional cohort of 197 patients with stage III NSCLC treated with concurrent chemoradiation (cCRT) and durvalumab consolidation, we identify that low tumor aneuploidy is independently associated with prolonged progression-free survival (HR 0.63; p=0.03) and overall survival (HR 0.50; p=0.03). Tumors with high aneuploidy had a significantly greater incidence of distant metastasis and shorter median distant-metastasis free survival (p=0.04 and p=0.048, respectively), but aneuploidy level did not associate with local-regional outcomes. Multiplexed immunofluorescence analysis in a cohort of NSCLC found increased intratumoral CD8-positive, PD-1-positive cells, double-positive PD-1 CD8 cells, and FOXP3-positive T-cell in low aneuploid tumors. Additionally, in a cohort of 101 patients treated with cCRT alone, tumor aneuploidy did not associate with disease outcomes. These data support the need for upfront treatment intensification strategies in stage III NSCLC patients with high aneuploid tumors and suggest that tumor aneuploidy is a promising predictive biomarker.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos