Clinical Effect of Rehabilitation New Fluid Combined with Sanjie Analgesic Capsules in the Treatment of Granulomatous Mastitis and Thyroiditis and Impact on Immune Indexes of Patients.
Altern Ther Health Med
; 2023 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-37971448
ABSTRACT
Objective:
To analyze the clinical effect of rehabilitation new fluid combined with Sanjie analgesic capsules in the treatment of granulomatous lobular mastitis (GLM) and thyroiditis and the impact on immune indexes of patients.Methods:
For a retrospective study, we selected 150 patients with GLM and 150 patients with thyroiditis admitted to The Fourth Hospital of Shijiazhuang from January 2021 to January 2022. We divided them into three groups based on the treatment methods. Control group 1 (CG1) included patients treated with rehabilitation new fluid alone, while control group 2 (CG2) included patients treated with the Sanjie analgesic capsules alone. The third group, the observation group (OG), included patients treated with rehabilitation new fluid (extract of drying body from Periplaneta americana) at an oral dose of 10 ml combined with Sanjie analgesic capsules. There were 50 patients in each group. The clinical efficacy, symptom improvement, the level changes of free triiodothyronine (FT3), free tetraiodothyronine (FT4), and thyroid stimulating hormone (TSH), and the changes of immune indexes such as CD4+ (cluster of differentiation 4+), CD25+ (cluster of differentiation 25+), CD68+ (cluster of differentiation 68+) and CD138+ (cluster of differentiation 138+) were analyzed.Results:
After treatment, the total treatment effectiveness of GLM in the OG was 94%, which was significantly higher than 80% in the CG1 and 78% in the CG2 (P = .037, .021), while the total treatment effectiveness of thyroiditis in the OG was 92%, which was significantly higher than 76% in the CG1 and 74% in the CG2 (P = .029, 0.017). The scores of breast pain, breast overflow, tumor size, local skin changes, and axillary fossa lymphadenectasis of the affected side in the OG of GLM were better than those in CG1 (Pbreast pain < .001, 95%CI 0.573-1.747; Pbreast overflow = .022, 95%CI 0.074-0.905; Ptumor size = .008, 95%CI 0.231-1.489; Plocal skin changes = .001, 95%CI 0.382-1.498; Paxillary fossa lymphadenectasis of the affected side = .011, 95%CI 0.096-0.704) and CG2 (Pbreast pain = .001, 95%CI 0.449-1.711; Pbreast overflow = .049, 95%CI 0.002-0.798; Ptumor size =0.019, 95%CI 0.132-1.428; Plocal skin changes < .001, 95%CI 0.563-1.517; Paxillary fossa lymphadenectasis of the affected side = .001, 95%CI 0.202-0.678). The levels of FT3 and FT4 in the OG of thyroiditis were higher than CG1 (PFT3 < .001, 95%CI 0.951-1.590; PFT4 < .001, 95%CI 1.421-2.618) and CG2 (PFT3 < .001, 95%CI 0.943-1.643; PFT4 < .001, 95%CI 1.521-2.758), and the TSH level was lower compared with CG1 (PTSH < .001, 95%CI 2.409-3.070) and CG2 (PTSH < .001, 95%CI 2.540-3.230). The immune indexes of GLM were improved, and the levels of CD4+, CD25+, CD68+, and CD138+ in the OG were better than those in the CG1 (PCD4+ < .001, 95%CI 2.967-4.912; PCD25+ < .001, 95%CI 3.707-5.212; PCD68+ < .001, 95%CI 1.445-2.200; PCD138+ < .001, 95%CI 3.922-5.510) and CG2 (PCD4+ < .001, 95%CI 3.093-4.995; PCD25+ < .001, 95%CI 3.527-4.904; PCD68+ < .001, 95%CI 1.334-2.216; PCD138+ < .001, 95%CI 3.878-5.352). The immune indexes of thyroiditis were improved, and the levels of CD4+, CD25+, CD68+, and CD138+ in the OG were better than those in the CG1 (PCD4+ < .001, 95%CI 4.235-6.117; PCD25+ < .001, 95%CI 3.300-4.810; PCD68+ < .001, 95%CI 1.173-1.939; PCD138+ < .001, 95%CI 3.704-4.881) and CG2 (PCD4+ < .001, 95%CI 3.136-5.422; PCD25+ < .001, 95%CI 3.182-4.615; PCD68+ < .001, 95%CI 1.216-2.113; PCD138+ < .001, 95%CI 4.145-5.527).Conclusion:
The clinical effect of rehabilitation new fluid combined with Sanjie analgesic capsule in the treatment of GLM and thyroiditis is remarkable, which enables enhancement of the treatment efficiency, and improves patients' clinical symptoms, functional indexes, and the levels of immune indexes, as a direction for the follow-up treatment in the clinic.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Altern Ther Health Med
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2023
Tipo de documento:
Article