[Gene therapy to cure HIV infection]. / Thérapie génique pour guérir l'infection par le VIH.
Virologie (Montrouge)
; 27(5): 284-306, 2023 Oct 01.
Article
em Fr
| MEDLINE
| ID: mdl-37991319
ABSTRACT
To date, the only intervention that has cured HIV infection has been bone marrow transplants from HIV-resistant donors to HIV-infected recipients. This approach has been used to both cure hematological malignancies and HIV infection, but it cannot be widely adopted due to the high risk of mortality associated with cell transplants between individuals. To overcome this limitation, several approaches have been developed to generate HIV resistance using gene therapy in an infected individual's own cells. With the growing arsenal of effective methods to generate HIV-resistant cells, a safe and effective combination gene therapy approach to cure HIV infection is fast approaching. Here, we review several gene therapy-based methods to generate HIV-resistant cells including the expression of antiviral genes, genome editing, and transcriptional gene silencing. Their varied mechanisms, advantages, and disadvantages are discussed, and perspectives are provided for how they may be combined to design an effective gene therapy for HIV.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Infecções por HIV
Limite:
Humans
Idioma:
Fr
Revista:
Virologie (Montrouge)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Canadá