How Impedance Measurements and Imaging Can Be Used to Characterize the Conductivity of Tissues During the Workflow of an Electroporation-Based Therapy.
IEEE Trans Biomed Eng
; 71(4): 1370-1377, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37995176
ABSTRACT
In this article we investigate the possibility of using needles, which the interventional radiologist inserts near a deep-seated tumor during an electroporation-based therapy, to characterize the electrical conductivity of patient's tissues. Specifically, we propose to exploit voltage/current measurements and imaging that are performed prior to the application of electroporation pulses. The approach is partly based on the concepts of electrical impedance tomography; however, imaging is used to build a specific geometric model and compensate for the lack of information resulting from the small number of electrodes available. 3D canonical and clinical examples, where a few electrodes surround a tumor, demonstrate the feasibility of this method:
solving the inverse problem to estimate tissues conductivity converges in a few iterations. For a given error on the measurement, it is also possible to calculate the error on the estimated conductivities. The uncertainty error with clinical data is at best 5% for one of the tissues identified, due to the limitations of the clinical device used. Various improvements to clinical devices are discussed to make the conductivity estimation more accurate but also to extract more information.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tomografia
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Ano de publicação:
2024
Tipo de documento:
Article