The discovery of a new potent FXR agonist based on natural product screening.

Yao, Zongwen; Chen, Lin; Hu, Min; Meng, Fancheng; Chen, Min; Wang, Guowei

Yao, Zongwen; Chen, Lin; Hu, Min; Meng, Fancheng; Chen, Min; Wang, Guowei.

Afiliação

Yao Z; College of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Chen L; College of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Hu M; College of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Meng F; College of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Chen M; College of Pharmaceutical Sciences, Southwest University, Chongqing, China. Electronic address: mminchen@swu.edu.cn.
Wang G; College of Pharmaceutical Sciences, Southwest University, Chongqing, China. Electronic address: wangguowei@swu.edu.cn.

Bioorg Chem ; 143: 106979, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37995646

Assuntos

Colestase; Sesquiterpenos; Camundongos; Animais; Simulação de Acoplamento Molecular; Fígado/metabolismo; Colestase/genética; Colestase/metabolismo; Colestase/prevenção & controle; Ácidos e Sais Biliares/metabolismo; Bilirrubina/metabolismo; Sesquiterpenos/farmacologia

Palavras-chave

FXR agonistic activity; Natural product screening; Sesquiterpenoids; Structural elucidation; Target validation; X. vielana

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Colestase Limite: Animals Idioma: En Revista: Bioorg Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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