IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events.

Fujiwara, Rina; Zhai, Si-Nan; Liang, Dongming; Shah, Aayushi P; Tracey, Matthew; Ma, Xu-Kai; Fields, Christopher J; Mendoza-Figueroa, María Saraí; Meline, Michele C; Tatomer, Deirdre C; Yang, Li; Wilusz, Jeremy E

Fujiwara, Rina; Zhai, Si-Nan; Liang, Dongming; Shah, Aayushi P; Tracey, Matthew; Ma, Xu-Kai; Fields, Christopher J; Mendoza-Figueroa, María Saraí; Meline, Michele C; Tatomer, Deirdre C; Yang, Li; Wilusz, Jeremy E.

Afiliação

Fujiwara R; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA.
Zhai SN; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Center for Molecular Medicine, Children's Hospital, Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epi
Liang D; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Shah AP; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA.
Tracey M; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Ma XK; Center for Molecular Medicine, Children's Hospital, Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Fields CJ; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA.
Mendoza-Figueroa MS; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Meline MC; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Tatomer DC; Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Yang L; Center for Molecular Medicine, Children's Hospital, Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Wilusz JE; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: jeremy.wilusz@bcm.edu.

Mol Cell ; 83(24): 4445-4460.e7, 2023 Dec 21.

Article em En | MEDLINE | ID: mdl-37995689

Assuntos

Proteínas de Drosophila; Terminação da Transcrição Genética; Animais; RNA; RNA Polimerase II/genética; RNA Polimerase II/metabolismo; RNA Nuclear Pequeno/genética; Fatores de Transcrição/metabolismo; Proteínas de Drosophila/metabolismo; Drosophila melanogaster

Palavras-chave

3' end processing; INTAC; Integrator complex; Integrator subunit 6; PP2A; RNA polymerase II; promoter-proximal termination; protein phosphatase 2A; snRNA; transcription

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Drosophila / Terminação da Transcrição Genética Limite: Animals Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google