Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics.

Shuttleworth, Joseph G; Lei, Chon Lok; Whittaker, Dominic G; Windley, Monique J; Hill, Adam P; Preston, Simon P; Mirams, Gary R

Shuttleworth, Joseph G; Lei, Chon Lok; Whittaker, Dominic G; Windley, Monique J; Hill, Adam P; Preston, Simon P; Mirams, Gary R.

Afiliação

Shuttleworth JG; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Lei CL; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.
Whittaker DG; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China.
Windley MJ; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Hill AP; 4 Systems Modeling & Translational Biology, Stevenage, GSK, UK.
Preston SP; Computational Cardiology Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Mirams GR; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.

Bull Math Biol ; 86(1): 2, 2023 11 24.

Article em En | MEDLINE | ID: mdl-37999811

Assuntos

Conceitos Matemáticos; Modelos Biológicos; Incerteza; Modelos Teóricos; Canais Iônicos

Palavras-chave

Discrepancy; Experimental design; Ion channel; Mathematical model; Misspecification; Uncertainty quantification

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Conceitos Matemáticos / Modelos Biológicos Idioma: En Revista: Bull Math Biol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google