Comparative protective efficacy of a newly generated live recombinant thermostable highly attenuated vaccine rK148/GVII-F using a single regimen against lethal NDV GVII.1.1.

Abdallah Mouhamed, Amal; Lee, Jiho; Kim, Deok-Hwan; Song, Chang-Seon

Abdallah Mouhamed, Amal; Lee, Jiho; Kim, Deok-Hwan; Song, Chang-Seon.

Afiliação

Abdallah Mouhamed A; Department of Avian Diseases, Animal Health Research Institute, Agriculture Research Center, Giza, Egypt.
Lee J; Department of Avian Disease and Infectious Disease, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Kim DH; Department of Avian Disease and Infectious Disease, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Song CS; KHAV Co. Ltd., Seoul, Republic of Korea.

Avian Pathol ; 53(1): 14-32, 2024 Feb.

Article em En | MEDLINE | ID: mdl-38009206

RESUMO

RESEARCH HIGHLIGHTS: A thermostable, safe, and effective NDV GVII recombinant vaccine was generated.Fusion gene replacement with GVII did not affect GI K148/08 virus thermostability.Strain rK148/GVII-F provided adequate protection against a lethal NDV challenge.Oropharyngeal shedding was significantly reduced on post-challenge days 5 and 7.

Assuntos

Doença de Newcastle; Doenças das Aves Domésticas; Vacinas Virais; Animais; Galinhas; Vírus da Doença de Newcastle/genética; Vacinas Atenuadas; Genótipo; Vacinas Sintéticas; Doenças das Aves Domésticas/prevenção & controle; Anticorpos Antivirais

Palavras-chave

Newcastle disease virus; genotype VII; protective efficacy; recombinant vaccine; thermostability; viral shedding

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Aves Domésticas / Vacinas Virais / Doença de Newcastle Limite: Animals Idioma: En Revista: Avian Pathol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Egito

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google