Effect of Modification Strategies on the Biological Activity of Peptides/Proteins.

Ma, Jian; Yan, Liang; Yang, Jingkui; He, Yujian; Wu, Li

Ma, Jian; Yan, Liang; Yang, Jingkui; He, Yujian; Wu, Li.

Afiliação

Ma J; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yan L; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yang J; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
He Y; School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Wu L; School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.

Chembiochem ; 25(3): e202300481, 2024 02 01.

Article em En | MEDLINE | ID: mdl-38009768

ABSTRACT

ABSTRACT

Covalent attachment of biologically active peptides/proteins with functional moieties is an effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and toxicity. This review focuses on the characteristics of different modification strategies and their effects on the biological activity of peptides/proteins and illustrates their relevant applications and potential.

Assuntos

Peptídeos; Proteínas; Distribuição Tecidual; Proteínas/metabolismo; Peptídeos/farmacologia; Peptídeos/metabolismo

Palavras-chave

N-terminal acetylation; PEGylation; biological activity; glycosylation; peptides/proteins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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