Isobavachin, a main bioavailable compound in Psoralea corylifolia, alleviates lipopolysaccharide-induced inflammatory responses in macrophages and zebrafish by suppressing the MAPK and NF-&#954;B signaling pathways.

Chung, You Chul; Song, Su Jeong; Lee, Ami; Jang, Chan Ho; Kim, Chan-Sik; Hwang, Youn-Hwan

Isobavachin, a main bioavailable compound in Psoralea corylifolia, alleviates lipopolysaccharide-induced inflammatory responses in macrophages and zebrafish by suppressing the MAPK and NF-κB signaling pathways.

Chung, You Chul; Song, Su Jeong; Lee, Ami; Jang, Chan Ho; Kim, Chan-Sik; Hwang, Youn-Hwan.

Afiliação

Chung YC; Herbal Medicine Research Division, Korea Institution of Oriental Medicine, Deajeon, 34054, Republic of Korea.
Song SJ; Herbal Medicine Research Division, Korea Institution of Oriental Medicine, Deajeon, 34054, Republic of Korea; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, 66047, USA.
Lee A; Herbal Medicine Research Division, Korea Institution of Oriental Medicine, Deajeon, 34054, Republic of Korea; Korean Convergence Medical Science Major, KIOM Campus, University of Science & Technology (UST), Deajeon, 34054, Republic of Korea.
Jang CH; Herbal Medicine Research Division, Korea Institution of Oriental Medicine, Deajeon, 34054, Republic of Korea.
Kim CS; Herbal Medicine Research Division, Korea Institution of Oriental Medicine, Deajeon, 34054, Republic of Korea; Korean Convergence Medical Science Major, KIOM Campus, University of Science & Technology (UST), Deajeon, 34054, Republic of Korea.
Hwang YH; Herbal Medicine Research Division, Korea Institution of Oriental Medicine, Deajeon, 34054, Republic of Korea; Korean Convergence Medical Science Major, KIOM Campus, University of Science & Technology (UST), Deajeon, 34054, Republic of Korea. Electronic address: hyhhwang@kiom.re.kr.

J Ethnopharmacol ; 321: 117501, 2024 Mar 01.

Article em En | MEDLINE | ID: mdl-38012970

Assuntos

Proteínas Quinases Ativadas por Mitógeno; Psoralea; Animais; Camundongos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Lipopolissacarídeos/farmacologia; Peixe-Zebra; Psoralea/metabolismo; Transdução de Sinais; Flavonoides/farmacologia; Citocinas/metabolismo; Macrófagos; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Anti-Inflamatórios/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Ciclo-Oxigenase 2/genética; Ciclo-Oxigenase 2/metabolismo

Palavras-chave

Anti-inflammatory agents; Isobavachin; Macrophages; Psoralea corylifolia; Zebrafish

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases Ativadas por Mitógeno / Psoralea Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2024 Tipo de documento: Article

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