Hesperidin Methyl Chalcone reduces extracellular Aß<sub>(25-35)</sub> peptide aggregation and fibrillation and also protects Neuro 2a cells from Aß<sub>(25-35)</sub> induced neuronal dysfunction.

Jafni, Sakthivel; Sathya, Sethuraman; Arunkumar, Malaisamy; Kiruthiga, Chandramohan; Jeyakumar, Mahalingam; Murugesh, Easwaran; Devi, Kasi Pandima

Hesperidin Methyl Chalcone reduces extracellular Aß_(25-35) peptide aggregation and fibrillation and also protects Neuro 2a cells from Aß_(25-35) induced neuronal dysfunction.

Jafni, Sakthivel; Sathya, Sethuraman; Arunkumar, Malaisamy; Kiruthiga, Chandramohan; Jeyakumar, Mahalingam; Murugesh, Easwaran; Devi, Kasi Pandima.

Afiliação

Jafni S; Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India.
Sathya S; Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India.
Arunkumar M; Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi 110067, India.
Kiruthiga C; Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India.
Jeyakumar M; Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India.
Murugesh E; Research Scientist, Bioinformatics Centre, GRC - Ganga Hospital, Coimbatore, India.
Devi KP; Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India. Electronic address: pdevik@alagappauniversity.ac.in.

Bioorg Med Chem ; 96: 117536, 2023 12 15.

Article em En | MEDLINE | ID: mdl-38016411

Assuntos

Doença de Alzheimer; Chalconas; Hesperidina; Fármacos Neuroprotetores; Humanos; Peptídeos beta-Amiloides/toxicidade; Peptídeos beta-Amiloides/metabolismo; Chalconas/farmacologia; Hesperidina/farmacologia; Amiloide; Fragmentos de Peptídeos/toxicidade; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/química; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/patologia

Palavras-chave

Alzheimer's disease; Amyloid beta; Anti-aggregation; Molecular dynamics; Neuroprotection; Toxicity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Chalconas / Doença de Alzheimer / Hesperidina Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google