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Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction.
Coyle, Christopher W; Knight, Kristopher A; Brown, Harrison C; George, Stephan N; Denning, Gabriela; Branella, Gianna M; Childers, Kenneth C; Spiegel, P Clint; Spencer, H Trent; Doering, Christopher B.
Afiliação
  • Coyle CW; Molecular and Systems Pharmacology Graduate Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Knight KA; Molecular and Systems Pharmacology Graduate Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Brown HC; Expression Therapeutics, Inc, Atlanta, Georgia, USA.
  • George SN; Expression Therapeutics, Inc, Atlanta, Georgia, USA.
  • Denning G; Expression Therapeutics, Inc, Atlanta, Georgia, USA.
  • Branella GM; Cancer Biology Graduate Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Childers KC; Chemistry Department, Western Washington University, Bellingham, Washington, USA.
  • Spiegel PC; Chemistry Department, Western Washington University, Bellingham, Washington, USA.
  • Spencer HT; Cell and Gene Therapy Program, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA.
  • Doering CB; Cell and Gene Therapy Program, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA. Electronic address: cdoerin@emory.edu.
J Thromb Haemost ; 22(3): 633-644, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38016519
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator IX / Hemofilia B Limite: Animals / Humans Idioma: En Revista: J Thromb Haemost Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator IX / Hemofilia B Limite: Animals / Humans Idioma: En Revista: J Thromb Haemost Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos