Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.
Alzheimers Dement
; 20(3): 1497-1514, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38018701
ABSTRACT
INTRODUCTION:
The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear.METHODS:
Using data from eight independent studies (Ntotal = 44,531; Ndementia = 1703; baseline Mage = 49 to 81 years, 26 to 61% female; Mfollow-up range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.RESULTS:
Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.DISCUSSION:
This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy. HIGHLIGHTS N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.Palavras-chave
Braak stage; CERAD; Lewy body disease; TDP-43; agreeableness; arteriosclerosis; cerebral amyloid angiopathy; cerebral atherosclerosis; extraversion; gross cerebral infarcts; gross cerebral microinfarcts; hippocampal sclerosis; individual participant data meta-analysis; openness; positive affect; satisfaction with life
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Personalidade
/
Demência
Tipo de estudo:
Systematic_reviews
Limite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos