Prenatal maternal cortisol, stress and anxiety, and childhood obesity at 5 years: a nested case-control study.
J Reprod Infant Psychol
; : 1-15, 2023 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-38018852
ABSTRACT
BACKGROUND:
Paediatric obesity is a global public health issue. Prenatal maternal mental health is potentially implicated in the development of childhood obesity. This study examined associations between prenatal maternal cortisol, self-reported stress, anxiety and depression in the second trimester, and childhood overweight and obesity at 5 years of age.METHODS:
A nested case-control study was conducted using data from the Irish prospective longitudinal birth cohort SCOPE BASELINE. Cases were children with overweight or obesity, operationalised as having a BMI z-score above +2 standard deviations. Controls were children with a BMI z-score between -0.5 and 0.5 standard deviations at 5 years of age. Two to one matching by sex was conducted. Thirty-eight cases and 83 sex-matched controls were included. Maternal serum cortisol concentration and self-reported stress, anxiety and depression were measured at 15 ± 1 and 20 ± 1 weeks gestation. Conditional logistic regression analyses were conducted to examine associations between prenatal maternal cortisol and self-reported stress, anxiety and depression, and childhood overweight and obesity.RESULTS:
Despite some evidence for associations between anxiety and depression, and child BMI z-scores in univariate analyses, adjusted models indicated no associations between prenatal maternal stress (OR 1.02, 95% CI 0.94-1.12), anxiety (OR 1.03, 95% CI 0.97-1.09), depression (OR 1.04, 95% CI 0.91-1.19), or cortisol concentration (OR 0.99, 95% CI 0.99-1.00) and child BMI z-score.CONCLUSION:
Our findings do not provide support for associations between foetal exposure during the second trimester of pregnancy and maternal cortisol, stress and anxiety, and childhood overweight or obesity at 5 years of age.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Reprod Infant Psychol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Irlanda