The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication.
Microbiol Spectr
; 12(1): e0260923, 2024 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-38038453
ABSTRACT
IMPORTANCE Influenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
/
Vírus da Influenza A
/
Vacinas contra Influenza
/
Influenza Humana
Limite:
Humans
Idioma:
En
Revista:
Microbiol Spectr
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Singapura