Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF-&#954;B and TGF-ß1/Smad2/3 pathways.

Hao, Wei; Yu, Ting-Ting; Zuo, Dong-Ze; Hu, Heng-Zhao; Zhou, Ping-Ping

Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF-κB and TGF-ß1/Smad2/3 pathways.

Hao, Wei; Yu, Ting-Ting; Zuo, Dong-Ze; Hu, Heng-Zhao; Zhou, Ping-Ping.

Afiliação

Hao W; Department of Functional Experimental Training Center, Basic Medical College, Wannan Medical College, Wuhu, China.
Yu TT; Department of Functional Experimental Training Center, Basic Medical College, Wannan Medical College, Wuhu, China.
Zuo DZ; Department of Pharmacy, Second People's Hospital of Hefei, Hefei, China.
Hu HZ; School of Anesthesiology, Wannan Medical College, Wuhu, China.
Zhou PP; Department of Physiology, Basic Medical College, Wannan Medical College, Wuhu, China.

Exp Lung Res ; 49(1): 205-219, 2023 11 20.

Article em En | MEDLINE | ID: mdl-38044666

Assuntos

Fibrose Pulmonar; Camundongos; Animais; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/tratamento farmacológico; Fibrose Pulmonar/metabolismo; NF-kappa B; Fator de Crescimento Transformador beta1/metabolismo; Bleomicina/efeitos adversos; Vimentina; Fator 2 Relacionado a NF-E2; Fator de Necrose Tumoral alfa; Interleucina-6; Colágeno/metabolismo; Colágeno Tipo I/metabolismo; Caderinas; Superóxido Dismutase

Palavras-chave

Stevioside; epithelial-mesenchymal transition; inflammatory response; oxidative stress; pulmonary fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Limite: Animals Idioma: En Revista: Exp Lung Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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