Promiscuity of Omphalotin A Biosynthetic Enzymes Allows de novo Production of Non-Natural Multiply Backbone N-Methylated Peptide Macrocycles in Yeast.

Matabaro, Emmanuel; Witte, Luca; Gherlone, Fabio; Vogt, Eva; Kaspar, Hannelore; Künzler, Markus

Matabaro, Emmanuel; Witte, Luca; Gherlone, Fabio; Vogt, Eva; Kaspar, Hannelore; Künzler, Markus.

Afiliação

Matabaro E; Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog Weg 4, HCI F423, 8093, Zürich, Switzerland.
Witte L; Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog Weg 4, HCI F423, 8093, Zürich, Switzerland.
Gherlone F; Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog Weg 4, HCI F423, 8093, Zürich, Switzerland.
Vogt E; Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog Weg 4, HCI F423, 8093, Zürich, Switzerland.
Kaspar H; Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog Weg 4, HCI F423, 8093, Zürich, Switzerland.
Künzler M; Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog Weg 4, HCI F423, 8093, Zürich, Switzerland.

Chembiochem ; 25(3): e202300626, 2024 02 01.

Article em En | MEDLINE | ID: mdl-38059521

Assuntos

Saccharomyces cerevisiae; Espectrometria de Massas em Tandem; Saccharomyces cerevisiae/metabolismo; Peptídeos/química; Peptídeos Cíclicos/química

Palavras-chave

Borosin; Komagataella phaffii; Macrocylization; RiPP; α-N-methylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Espectrometria de Massas em Tandem Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça

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