Acidic growth conditions stabilize the ribosomal RNA gene cluster and extend lifespan through noncoding transcription repression.

Hasegawa, Yo; Ooka, Hiroyuki; Wakatsuki, Tsuyoshi; Sasaki, Mariko; Yamamoto, Ayumi; Kobayashi, Takehiko

Hasegawa, Yo; Ooka, Hiroyuki; Wakatsuki, Tsuyoshi; Sasaki, Mariko; Yamamoto, Ayumi; Kobayashi, Takehiko.

Afiliação

Hasegawa Y; Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Bunkyo-ku, Japan.
Ooka H; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Japan.
Wakatsuki T; Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Bunkyo-ku, Japan.
Sasaki M; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Japan.
Yamamoto A; Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Bunkyo-ku, Japan.
Kobayashi T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Japan.

Genes Cells ; 29(2): 111-130, 2024 Feb.

Article em En | MEDLINE | ID: mdl-38069450

Assuntos

Longevidade; Transcrição Gênica; Animais; Genes de RNAr; DNA Ribossômico/genética; Extratos Vegetais; Mamíferos

Palavras-chave

acidity; blackcurrant; genome stability; histone deacetylase; lifespan; noncoding transcription; ribosomal RNA gene (rDNA); senescence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Longevidade Limite: Animals Idioma: En Revista: Genes Cells Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

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