Relationship between exposure to metalworking fluids and nonalcoholic fatty liver disease.
Int Arch Occup Environ Health
; 97(1): 57-64, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38070038
ABSTRACT
OBJECTIVE:
The relationship between metalworking fluids (MWFs) and nonalcoholic fatty liver disease (NAFLD) has not been previously explored. We aim to investigate the relationship between occupational exposure to MWFs and the prevalence of NAFLD and to determine the cumulative exposure threshold per day.METHODS:
In 2020, 2079 employees were selected randomly from one computer numerical control machining factory in Wuxi for a questionnaire survey, and occupational health examinations were conducted at the affiliated branch of Wuxi Eighth People's Hospital. MWF samples were collected within the factory using the National Institute for Occupational Safety and Health (NIOSH) 5524 method. NAFLD was defined as having a hepatic steatosis index (HSI) ≥ 36 without significant alcohol consumption. The relationship between NAFLD and MWFs was analyzed using logistic regression, and the daily exposure threshold was calculated using R software.RESULTS:
MWF exposure was found to be a risk factor for NAFLD in exposed workers compared to the non-exposed group. The OR for NAFLD in workers exposed to MWFs compared to controls was 1.42 (95% CI 1.04-1.95). An increased risk of NAFLD was shown to be associated with an increasing dose. The daily exposure dose threshold to MWFs was found to be 6.54 mg/m3 (OR = 2.09, 95% CI 1.24-3.52).CONCLUSION:
An association between occupational exposure to MWFs and NAFLD was found. As the concentration of exposure rose, the prevalence of NAFLD was also escalated.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exposição Ocupacional
/
Poluentes Ocupacionais do Ar
/
Hepatopatia Gordurosa não Alcoólica
Limite:
Humans
Idioma:
En
Revista:
Int Arch Occup Environ Health
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China