Targeting CGRP pathways and aura: A peripheral site with a central effect.
Cephalalgia
; 43(12): 3331024231212895, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38099600
ABSTRACT
Targeting CGRP-pathways has substantially expanded our options for treating individuals with migraine. Although the efficacy of these drugs on migraine aura is yet to be fully revealed, it seems from existing studies that CGRP antagonism reduces the number of migraine auras. The present perspective summarizes the evidence linking CGRP to the migraine aura and proposes a model by which targeting the CGRP-pathways and, thus, inhibition the interaction between C- and Aδ-trigeminal fibers might reverse a possible high cortical glutamate level leading to a reduced number of migraine auras.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depressão Alastrante da Atividade Elétrica Cortical
/
Enxaqueca com Aura
/
Epilepsia
/
Transtornos de Enxaqueca
Limite:
Humans
Idioma:
En
Revista:
Cephalalgia
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Dinamarca