Single-Cell RNA Sequencing Analysis of Microglia Dissected the Energy Metabolism and Revealed Potential Biomarkers in Amyotrophic Lateral Sclerosis.

Shen, Dingding; Ji, Yanan; Qiu, Chong; Wang, Kexin; Gao, Zihui; Liu, Boya; Shen, Yuntian; Gong, Leilei; Yang, Xiaoming; Chen, Xin; Sun, Hualin; Yao, Xinlei

Shen, Dingding; Ji, Yanan; Qiu, Chong; Wang, Kexin; Gao, Zihui; Liu, Boya; Shen, Yuntian; Gong, Leilei; Yang, Xiaoming; Chen, Xin; Sun, Hualin; Yao, Xinlei.

Afiliação

Shen D; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Ji Y; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Qiu C; Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Wang K; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Gao Z; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Liu B; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Shen Y; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Gong L; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Yang X; Research and Development Center for E-Learning, Ministry of Education, Beijing, 100816, People's Republic of China.
Chen X; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China.
Sun H; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China. 5200339@ntu.edu.cn.
Yao X; Department of Neurology, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People's Republic of China. sunhl@ntu.edu.cn.

Mol Neurobiol ; 61(7): 4473-4487, 2024 Jul.

Article em En | MEDLINE | ID: mdl-38102515

Assuntos

Esclerose Lateral Amiotrófica; Biomarcadores; Metabolismo Energético; Microglia; Análise de Célula Única; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Esclerose Lateral Amiotrófica/patologia; Microglia/metabolismo; Microglia/patologia; Animais; Metabolismo Energético/genética; Humanos; Biomarcadores/metabolismo; Análise de Sequência de RNA/métodos; Camundongos; Camundongos Transgênicos; Masculino; Superóxido Dismutase-1/genética; Superóxido Dismutase-1/metabolismo; Feminino

Palavras-chave

ALS; Microglia; Oxidative phosphorylation; Single-cell RNA sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Microglia / Metabolismo Energético / Análise de Célula Única / Esclerose Lateral Amiotrófica Limite: Animals / Female / Humans / Male Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article

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