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Enhanced cannabis timeline followback (EC-TLFB): Comprehensive assessment of cannabis use including standard THC units and validation through biological measures.
Petrilli, Kat; Lawn, Will; Lees, Rachel; Mokrysz, Claire; Borissova, Anya; Ofori, Shelan; Trinci, Katie; Dos Santos, Renato; Leitch, Harry; Soni, Shilpa; Hines, Lindsey A; Lorenzetti, Valentina; Curran, H Valerie; Freeman, Tom P.
Afiliação
  • Petrilli K; Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
  • Lawn W; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Lees R; Department of Addictions, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Mokrysz C; Clinical Psychopharmacology Unit, University College London, London, UK.
  • Borissova A; Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
  • Ofori S; Clinical Psychopharmacology Unit, University College London, London, UK.
  • Trinci K; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Dos Santos R; NIHR University College London Hospitals Biomedical Research Centre, University College Hospital, London, UK.
  • Leitch H; Clinical Psychopharmacology Unit, University College London, London, UK.
  • Soni S; Clinical Psychopharmacology Unit, University College London, London, UK.
  • Hines LA; Jazz Pharmaceuticals at Kent Science Park, Sittingbourne, UK.
  • Lorenzetti V; Clinical Psychopharmacology Unit, University College London, London, UK.
  • Curran HV; Clinical Psychopharmacology Unit, University College London, London, UK.
  • Freeman TP; Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
Addiction ; 119(4): 772-783, 2024 04.
Article em En | MEDLINE | ID: mdl-38105033
ABSTRACT

AIMS:

The aims of this study were to present an enhanced cannabis timeline followback (EC-TLFB) enabling comprehensive assessment of cannabis use measures, including standard tetrahydrocannabinol (THC) units, and to validate these against objectively indexed urinary 11-nor-9-carboxy-tetrahydrocannabinol (THC-COOH) concentrations.

DESIGN:

We used cross-sectional baseline data from the 'CannTeen' observational longitudinal study.

SETTING:

The study was conducted in London, UK.

PARTICIPANTS:

A total of 147 participants who used cannabis regularly took part in the study (n = 71 female, n = 76 male; mean age = 21.90, standard deviation = 5.32). MEASUREMENTS The EC-TLFB was used to calculate frequency of cannabis use, method of administration, including co-administration with tobacco, amount of cannabis used (measured with unaided self-report and also using pictorial aided self-report) and type of cannabis product (flower, hash) which was used to estimate THC concentration (both from published data on THC concentration of products and analysis of cannabis samples donated by participants in this study). We calculated total weekly standard THC units (i.e. 5 mg THC for all cannabis products and methods of administration) using the EC-TLFB. The outcome variable for validation of past week EC-TLFB assessments was creatinine-normalized carboxy-tetrahydrocannabinol (THC-COOH) in urine.

FINDINGS:

All measures of cannabis exposure included in this analysis were positively correlated with levels of THC-COOH in urine (r = 0.41-0.52). Standard THC units, calculated with average concentrations of THC in cannabis in the UK and unaided self-report measures of amount of cannabis used in grams showed the strongest correlation with THC-COOH in urine (r = 0.52, 95% bias-corrected and accelerated = 0.26-0.70).

CONCLUSIONS:

The enhanced cannabis timeline followback (EC-TLFB) can provide a valid assessment of a comprehensive set of cannabis use measures including standard tetrahydrocannabinol units as well as and traditional TLFB assessments (e.g. frequency of use and grams of cannabis use).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cannabis / Alucinógenos Limite: Adult / Female / Humans / Male Idioma: En Revista: Addiction Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cannabis / Alucinógenos Limite: Adult / Female / Humans / Male Idioma: En Revista: Addiction Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido