The role of inflammatory processes and zinc levels in prostatic enlargement among Iraqi samples.
J Med Life
; 16(9): 1388-1392, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-38107701
ABSTRACT
This study aimed to investigate the role of inflammatory processes in benign prostatic enlargement among men with elevated prostate-specific antigen (PSA) levels without a history of prostatic disease. Additionally, we aimed to examine the influence of serum zinc levels on prostate volume. We investigated the associations between systemic inflammatory markers, serum PSA, and serum zinc levels in 48 men without a history of prostatic disease, aged between 60-72 years, and 30 healthy men in the same age range. Data collection occurred between 1/2/2022 to 1/10/2022. The results are presented as mean values ± standard error (SE), and statistical significance was determined at p≤0.05. The levels of sIL-8 (P 44.295±1.002, C 1.404±0.2562), IL-6 (P 7.406±0.5632, C 4.468±0.830), CRP (P 14.765±0.565, C 6.267±0.538), increased significantly in patients with high PSA, while zinc levels (P 92.305±2.8235, C 114.565±8.861) decreased in the patient group. Regarding white blood cell (WBC) parameters, patients exhibited a significant increase in WBC total count (P 12995.00±488.47, C 7713.333±777.778), neutrophil % (P 69.450±1.619, C 51.200±1.826), lymphocyte % (P 39.50±2.024, C 30.867±1.268), and NLR (2.013±0.105). Conversely, there were no significant differences in eosinophil % (P 3.450±0.4558, C 3.267±0.5297), basophil % (P 0.300±0.105, C 0.267±1182), or monocyte % (P 3.450±0.4558, C 3.267±0.5297) between the two groups. In men without known prostatic illness, increased PSA was linked to markers of systemic inflammation. The results indicate the role of inflammatory processes in increasing the size of the prostate gland, as evidenced by the increased levels of immune markers like white blood cells and interleukins, along with the influence of zinc. Future research is required to determine how these markers relate to the development and incidence of prostate cancer.
Palavras-chave
AUR: Acute Urinary Retention; BPH: Benign Prostatic Hyperplasia; CRP; CRP: C-Reactive Protein; ESR: Erythrocyte Sedimentation Rate; IL-6: Interleukin-6; IL-8: Interleukin-8; IL6; IL8; MCP-1: Monocyte Chemoattractant Protein-1; NLR: Neutrophil-Lymphocyte Ratio; PC: Prostate Cancer; PLR: Platelet-Lymphocyte Ratio; PSA; PSA: Prostate-Specific Antigen; SIL-8: Serum Interleukin-8; WBC count; WBC: White Blood Cell Count; Zinc
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hiperplasia Prostática
/
Neoplasias da Próstata
Limite:
Aged
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Med Life
Assunto da revista:
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Iraque