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Increased cortical inhibition following brief motor memory reactivation supports reconsolidation and overnight offline learning gains.
Eisenstein, Tamir; Furman-Haran, Edna; Tal, Assaf.
Afiliação
  • Eisenstein T; Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Furman-Haran E; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Tal A; Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Proc Natl Acad Sci U S A ; 120(52): e2303985120, 2023 Dec 26.
Article em En | MEDLINE | ID: mdl-38113264
ABSTRACT
Practicing motor skills stabilizes and strengthens motor memories by repeatedly reactivating and reconsolidating them. The conventional view, by which a repetitive practice is required for substantially improving skill performance, has been recently challenged by behavioral experiments, in which even brief reactivations of the motor memory have led to significant improvements in skill performance. However, the mechanisms which facilitate brief reactivation-induced skill improvements remain elusive. While initial memory consolidation has been repeatedly associated with increased neural excitation and disinhibition, reconsolidation has been shown to involve a poorly understood mixture of both excitatory and inhibitory alterations. Here, we followed a 3-d reactivation-reconsolidation framework to examine whether the excitatory/inhibitory mechanisms which underlie brief reactivation and repetitive practice differ. Healthy volunteers practiced a motor sequence learning task using either brief reactivation or repetitive practice and were assessed using ultrahigh field (7T) magnetic resonance spectroscopy at the primary motor cortex (M1). We found that increased inhibition (GABA concentrations) and decreased excitation/inhibition (glutamate/GABA ratios) immediately following the brief reactivation were associated with overnight offline performance gains. These gains were on par with those exhibited following repetitive practice, where no correlations with inhibitory or excitatory changes were observed. Our findings suggest that brief reactivation and repetitive practice depend on fundamentally different neural mechanisms and that early inhibition-and not excitation-is particularly important in supporting the learning gains exhibited by brief reactivation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consolidação da Memória / Aprendizagem Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Israel

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consolidação da Memória / Aprendizagem Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Israel