Enantioselective α-Amination of Amides by One-Pot Organo-/Iodine Sequential Catalysis.
Org Lett
; 26(1): 258-263, 2024 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-38157251
ABSTRACT
An one-pot organo- and iodine sequential catalysis strategy for reactions of amides with pyrazole-based primary amines was described to synthesize chiral α-amino amides with a quaternary stereocenter. This methodology exhibited strong asymmetric induction, resulting in a typical enantiomeric excess value exceeding 99% and diastereoselectivity up to >991 dr. Moreover, the reaction was conducted without the use of any metals or strong bases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China