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Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing 1H MRI.
Capaldi, Dante P I; Konyer, Norman B; Kjarsgaard, Melanie; Dvorkin-Gheva, Anna; Dandurand, Ronald J; Nair, Parameswaran; Svenningsen, Sarah.
Afiliação
  • Capaldi DPI; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
  • Konyer NB; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
  • Kjarsgaard M; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
  • Dvorkin-Gheva A; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
  • Dandurand RJ; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
  • Nair P; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
  • Svenningsen S; From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K.,
Radiol Cardiothorac Imaging ; 5(6): e230054, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38166343
ABSTRACT
Purpose To determine if proton (1H) MRI-derived specific ventilation is responsive to bronchodilator (BD) therapy and associated with clinical biomarkers of type 2 airway inflammation and airways dysfunction in severe asthma. Materials and Methods In this prospective study, 27 participants with severe asthma (mean age, 52 years ± 9 [SD]; 17 female, 10 male) and seven healthy controls (mean age, 47 years ± 16; five female, two male), recruited between 2018 and 2021, underwent same-day spirometry, respiratory oscillometry, and tidal breathing 1H MRI. Participants with severe asthma underwent all assessments before and after BD therapy, and type 2 airway inflammatory biomarkers were determined (blood eosinophil count, sputum eosinophil percentage, sputum eosinophil-free granules, and fraction of exhaled nitric oxide) to generate a cumulative type 2 biomarker score. Specific ventilation was derived from tidal breathing 1H MRI and its response to BD therapy, and relationships with biomarkers of type 2 airway inflammation and airway dysfunction were evaluated. Results Mean MRI specific ventilation improved with BD inhalation (from 0.07 ± 0.04 to 0.11 ± 0.04, P < .001). Post-BD MRI specific ventilation (P = .046) and post-BD change in MRI specific ventilation (P = .006) were greater in participants with asthma with type 2 low biomarkers compared with participants with type 2 high biomarkers of airway inflammation. Post-BD change in MRI specific ventilation was correlated with change in forced expiratory volume in 1 second (r = 0.40, P = .04), resistance at 5 Hz (r = -0.50, P = .01), resistance at 19 Hz (r = -0.42, P = .01), reactance area (r = -0.54, P < .01), and reactance at 5 Hz (r = 0.48, P = .01). Conclusion Specific ventilation evaluated with tidal breathing 1H MRI was responsive to BD therapy and was associated with clinical biomarkers of airways disease in participants with severe asthma. Keywords MRI, Severe Asthma, Ventilation, Type 2 Inflammation Supplemental material is available for this article. © RSNA, 2023 See also the commentary by Moore and Chandarana in this issue.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prótons / Asma Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prótons / Asma Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Ano de publicação: 2023 Tipo de documento: Article