The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10â¯years of clinical literature and treatment implications.
Front Neuroendocrinol
; 73: 101119, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38184208
ABSTRACT
Rates of alcohol use disorder (AUD) are increasing in men and women and there are high rates of concurrent posttraumatic stress disorder (PTSD) and AUD. AUD and PTSD synergistically increase symptomatology and negatively affect treatment outcomes; however, there are very limited pharmacological treatments for PTSD/AUD. Neurosteroids have been implicated in the underlying neurobiological mechanisms of both PTSD and AUD and may be a target for treatment development. This review details the past ten years of research on pregnenolone, progesterone, allopregnanolone, pregnanolone, estradiol, testosterone and dehydroepiandrosterone/dehydroepiandrosterone-sulfate (DHEA/DHEA-S) in the context of PTSD and AUD, including examination of trauma/alcohol-related variables, such as stress-reactivity. Emerging evidence that exogenous pregnenolone, progesterone, and allopregnanolone may be promising, novel interventions is also discussed. Specific emphasis is placed on examining the application of sex as a biological variable in this body of literature, given that women are more susceptible to both PTSD diagnoses and stress-related alcohol consumption.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Estresse Pós-Traumáticos
/
Alcoolismo
/
Neuroesteroides
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Front Neuroendocrinol
/
Front. neuroendocrinol
/
Frontiers in neuroendocrinology
Ano de publicação:
2024
Tipo de documento:
Article