Triggered Seizures for Ictal SPECT Imaging: A Case Series and Feasibility Study.
J Nucl Med
; 65(3): 470-474, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38212073
ABSTRACT
Ictal SPECT is an informative seizure imaging technique to tailor epilepsy surgery. However, capturing the onset of unpredictable seizures is a medical and logistic challenge. Here, we sought to image planned seizures triggered by direct stimulation of epileptic networks via stereotactic electroencephalography (sEEG) electrodes. Methods:
In this case series of 3 adult participants with left temporal epilepsy, we identified and stimulated sEEG contacts able to trigger patient-typical seizures. We administered 99mTc-HMPAO within 12 s of ictal onset and acquired SPECT images within 40 min without any adverse events.Results:
Ictal hyperperfusion maps partially overlapped concomitant sEEG seizure activity. In both participants known for periictal aphasia, SPECT imaging revealed hyperperfusion in the speech cortex lacking sEEG coverage.Conclusion:
Triggering of seizures for ictal SPECT complements discrete sEEG sampling with spatially complete images of early seizure propagation. This readily implementable method revives interest in seizure imaging to guide resective epilepsy surgery.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Epilepsia
Limite:
Adult
/
Humans
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suíça