[Isolated liver involvement in Langerhans cell histiocytosis: A case report]. / Localisation hépatique isolée d'une histiocytose langerhansienne : à propos d'un cas.
Ann Pathol
; 44(1): 69-74, 2024 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-38216436
ABSTRACT
Langerhans cell histiocytosis (LCH) is a disease whose physiopathology remains unclear, involving both inflammatory processes and clonal proliferation. It is observable at any given age, although about ten times more frequent in children than adults. Hepatic involvement is not rare, mostly part of a systemic disease, and linked to a poor prognosis. We report here a case of LCH with solitary hepatic involvement in a 74 year-old patient. This case demonstrated molecular anomaly of the MAPK pathway, BRAF N486_P490del. Through this observation, we precise the epidemiological and histological aspects and diagnostic criteria of this rare disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histiocitose de Células de Langerhans
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
/
Humans
Idioma:
Fr
Revista:
Ann Pathol
Ano de publicação:
2024
Tipo de documento:
Article