Identification of thienopyrimidine derivatives tethered with sulfonamide and other moieties as carbonic anhydrase inhibitors: Design, synthesis and anti-proliferative activity.

Higazy, Samah; Samir, Nermin; El-Khouly, Ahmed; Giovannuzzi, Simone; Begines, Paloma; Gaber, Hatem M; Supuran, Claudiu T; Abouzid, Khaled A M

Higazy, Samah; Samir, Nermin; El-Khouly, Ahmed; Giovannuzzi, Simone; Begines, Paloma; Gaber, Hatem M; Supuran, Claudiu T; Abouzid, Khaled A M.

Afiliação

Higazy S; Egyptian Drug Authority, Cairo, Egypt.
Samir N; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
El-Khouly A; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Sadat City, Egypt; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jerash University, Jordan.
Giovannuzzi S; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Begines P; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Gaber HM; Egyptian Drug Authority, Cairo, Egypt.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy. Electronic address: claudiu.supuran@unifi.it.
Abouzid KAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt. Electronic address: khaled.abouzid@pharma.asu.edu.eg.

Bioorg Chem ; 144: 107089, 2024 Mar.

Article em En | MEDLINE | ID: mdl-38237393

Assuntos

Inibidores da Anidrase Carbônica; Anidrases Carbônicas; Pirimidinas; Inibidores da Anidrase Carbônica/química; Estrutura Molecular; Relação Estrutura-Atividade; Simulação de Acoplamento Molecular; Anidrases Carbônicas/metabolismo; Antígenos de Neoplasias/metabolismo; Sulfonamidas/química; Isoformas de Proteínas/metabolismo

Palavras-chave

Antiproliferative activity; Carbonic anhydrase; Synthesis; Thienopyrimine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores da Anidrase Carbônica / Anidrases Carbônicas Tipo de estudo: Diagnostic_studies Idioma: En Revista: Bioorg Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Egito

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