Goreisan regulates cerebral blood flow according to barometric pressure fluctuations in female C57BL/6J mice.
J Pharmacol Sci
; 154(2): 47-51, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38246727
ABSTRACT
Goreisan is a Kampo medicine used to treat headaches associated with climate change. Here, by using an implantable complementary metal-oxide-semiconductor (CMOS) device, we evaluated the effects of Goreisan and loxoprofen on cerebral blood flow (CBF) dynamics associated with barometric pressure fluctuations in freely moving mice. In the vehicle group, decreasing barometric pressure increased CBF that was prevented by Goreisan and loxoprofen. Notably, Goreisan, but not loxoprofen, reduced CBF after returning to atmospheric pressure. These results indicate that, unlike the mechanism of action of antipyretic analgesics, Goreisan normalizes CBF abnormalities associated with barometric pressure fluctuations by actively reducing CBF increase.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilpropionatos
/
Pressão Atmosférica
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Medicamentos de Ervas Chinesas
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Circulação Cerebrovascular
Limite:
Animals
Idioma:
En
Revista:
J Pharmacol Sci
/
J. pharmacol. sci
/
Journal of pharmacological sciences
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article