Your browser doesn't support javascript.
loading
The relationship between gray/white matter contrast and cognitive performance in first-episode schizophrenia.
Kobayashi, Haruko; Sasabayashi, Daiki; Takahashi, Tsutomu; Furuichi, Atsushi; Kido, Mikio; Takayanagi, Yoichiro; Noguchi, Kyo; Suzuki, Michio.
Afiliação
  • Kobayashi H; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
  • Sasabayashi D; Research Center for idling Brain Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
  • Takahashi T; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
  • Furuichi A; Research Center for idling Brain Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
  • Kido M; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
  • Takayanagi Y; Research Center for idling Brain Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
  • Noguchi K; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
  • Suzuki M; Research Center for idling Brain Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Cereb Cortex ; 34(2)2024 01 31.
Article em En | MEDLINE | ID: mdl-38265871
ABSTRACT
Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Substância Branca Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Substância Branca Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão